Taking place twenty years after the Metagen-92 virus – aka the “Superflu” – has swept the world and rendered many of its adult population superpowered or mutated, Origin Story follows MC (name customizable), a seemingly normal nineteen-year-old who in any other universe would be a popular and attractive prospect for most girls. But in this universe, his ability hasn't manifested yet. Shunned by most of his meta-gifted peers, MC finds himself a hapless virgin on the lower rung of his college's social ladder, with only a few misfit friends by his side.

Following the death of his parents when he was just a baby, his upbringing in the system was overseen and financially supported by their close friend Parker Samson, the affluent and influential co-owner of the lead organization behind Metagen research and development of the now ineffective Metagen Vaccine. Having recently moved in with the beautiful Parker, and her equally beautiful daughter Riley, MC finds the perpetual state of arousal that comes with the burden of his virginity even more challenging.

When MC is targeted and violently attacked for reasons unknown to him, The Sisterhood – a government-backed team of celebrity superheroines and sex icons - comes to his aid. While under their care, The Sisterhood immediately recognize his worth and hidden charms.

MC soon finds himself juggling college life, his suddenly blossoming relationships with the women he keeps close, his curious involvement with The Sisterhood and one big secret that could determine whether this is the origin story of a hero, or a villain.