The X-Change 2, you once again take on the role of Takuya Aihara was lucky chemistry student Miyanomori Private School, which has a tendency to get into the strange occurrences of chemistry, which cause a lot of problems. When you have made a strange chemical girl last year, you had a strange experience in the line, how do you know "how to live in the other half." Now, a year later, you will enjoy your school life with Asuka, your girlfriend is stable. But the unhappy days of the corner as a member of the chemistry club Chisato uses you as a guinea pig for a new experiment in which changes into a girl again!