Sam, Alex, and Clover are enjoying their adult lives, since their last adventure into the dangerous world of being spies of W.O.O.H.P. Just as they were about to attend a concert, Jerry calls them up for a mission of great importance that involves human trafficking involving miniaturized women who just turned 21 on their birthdays and a former spy member is involved in it, using one of W.O.O.H.P.'s gadgets to shrink them. Their mission to to find out what's going on and retrieve the stolen gadget. Plain and simple, right?
Things start to awry when the GPS of where the gadget is tracks it to a house very familiar to them: Mandy's house! As if that's not bad enough, they're shrinking without warning, their gadgets malfunctioned, and call to Jerry is out of service, not realizing that W.O.O.H.P. went on lock-down due to a breach in the system.
With everything wrong during the search, they're on their own...until Mandy shows up...and she's wanting her payback for so many things they did to make her life miserable. And seeing the three shrinking before her eyes makes her want to relish the moment in the most erotic thing possible, to make them hers. But this is just the beginning, as a familiar escapee is plotting her revenge on the trio.
